article Open AccessTop 10% cited
Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging
Alimentary Pharmacology & Therapeutics · 2005 · Vol. 22(10) · pp. 971–979
Carsten Schiller✉(Universität Greifswald)Carolin Fröhlich(Universität Greifswald)Thomas Gießmann(Universität Greifswald)Werner Siegmund(Universität Greifswald)Hubert Mönnikes(Charité - Universitätsmedizin Berlin)Norbert Hosten(Universität Greifswald)Werner Weitschies(Universität Greifswald)
Abstract
The results show that fluid is not homogeneously distributed along the gut, which likely contributes to the individual variability of drug absorption. Furthermore, transport of fluid and solids through the ileocaecal valve is obviously initiated by a meal-induced gastro-ileocaecal reflex.
Gastrointestinal motility and disordersDiet and metabolism studiesIon Transport and Channel RegulationMedicineMagnetic resonance imagingGastrointestinal transitNuclear magnetic resonanceRadiologyInternal medicinePhysics
MeSH terms
AdultBody WaterCapsulesColonFemaleGastrointestinal TransitHumansMagnetic Resonance ImagingMaleMiddle Aged
Funding
- Deutsche Forschungsgemeinschaft
Citations
590
FWCI
4.04
field-weighted impact
References
21
Percentile
94%
vs. same field & year
Citations per year
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