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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
Bioorganic & Medicinal Chemistry Letters · 1998 · Vol. 8(20) · pp. 2839–2844
John V. Duncia✉(Experimental Station)Joseph B. Santella(DuPont (United States))C. Anne Higley(Experimental Station)William J. Pitts(Wilmington University)John Wityak(Experimental Station)William E. Frietze(Experimental Station)F. Wayne Rankin(Experimental Station)Jung-Hui Sun(Experimental Station)Richard A. Earl(DuPont (United States))A. Christine Tabaka(Wilmington University)Christopher A. Teleha(Wilmington University)Karl F. Blom(DuPont (United States))Margaret Favata(Experimental Station)Elizabeth J. Manos(Wilmington University)Andrea J. Daulerio(Experimental Station)Deborah A. Stradley(Experimental Station)Kurumi Y. Horiuchi(Wilmington University)Robert A. Copeland(Experimental Station)Peggy Scherle(Wilmington University)James M. Trzăskos(Wilmington University)Ronald L. Magolda(Wilmington University)George L. Trainor(Wilmington University)Ruth R. Wexler(DuPont (United States))Frank W. Hobbs(Experimental Station)Richard E. Olson(Experimental Station)
Melanoma and MAPK PathwaysCytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase SignalingChemistryIn vivoIsomerizationKinaseMechanism of actionStructure–activity relationshipProtein kinase AIC50StereochemistryIn vitro
MeSH terms
AnimalsAnti-Inflammatory AgentsBiotransformationButadienesCyclizationEnzyme InhibitorsNitrilesNF-kappa BProtein Serine-Threonine KinasesTranscription Factor AP-1Rats
Citations
404
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2.28
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11
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89%
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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Journal of Biological Chemistry · 1998 · 3,023 citations
The nuclear receptor superfamily: The second decade
Cell · 1995 · 6,961 citations
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