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Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening

Bioorganic & Medicinal Chemistry · 2006 · Vol. 14(14) · pp. 4792–4802
Nicolas FoloppeLisa M. FisherRob HowesAndrew PotterAlan RobertsonA.E. Surgenor
Enzyme Structure and FunctionDNA Repair MechanismsComputational Drug Discovery MethodsChemistryVirtual screeningDocking (animal)Binding siteComputational biologySmall moleculeContext (archaeology)KinaseDrug discoveryChemical biology

MeSH terms

Checkpoint Kinase 1Adenosine TriphosphateBinding SitesBinding, CompetitiveDrug Evaluation, PreclinicalHumansLigandsModels, MolecularProtein KinasesUser-Computer InterfaceMolecular StructureCrystallography, X-RayProtein Kinase InhibitorsIn Vitro Techniques
Citations
362
FWCI
4.23
field-weighted impact
References
68
Percentile
95%
vs. same field & year
Citations per year
References
All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins
The Journal of Physical Chemistry B · 1998 · 14,418 citations
Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking
Proteins Structure Function and Bioinformatics · 1999 · 894 citations
The Protein Data Bank
Nucleic Acids Research · 2000 · 39,191 citations
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Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening · Scinovex