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Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins

Arthritis & Rheumatism · 2000 · Vol. 43(1) · pp. 30–37

Alex J. MacGregor✉(St Thomas' Hospital)Harold Snieder(St Thomas' Hospital)Alan S. Rigby(Boston Children's Hospital)Markku Koskenvuo(University of Turku)Jaakko Kaprio(University of Helsinki)Kimmo Aho(Institute for Molecular Medicine Finland)Alan J. Silman(University of Manchester)

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Abstract

Genetic factors have a substantial contribution to RA in the population, accounting for approximately 60% of the variation in liability to disease. Although tempered by power considerations, there is no evidence in these twin data that the overall genetic contribution to RA differs by sex, age, age at disease onset, and disease severity.

Rheumatoid Arthritis Research and Therapies Systemic Lupus Erythematosus Research Chronic Lymphocytic Leukemia ResearchHeritabilityConcordanceMedicineDiseaseDemographyTwin studyRheumatoid arthritisPopulationConfidence intervalGenetic model

MeSH terms

AdultAgedArthritis, RheumatoidCross-Sectional StudiesFemaleFinlandUnited KingdomHumansMaleMiddle AgedModels, GeneticCohort StudiesGenetic HeterogeneityQuantitative Trait, HeritableGenetic Predisposition to Disease

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Management of Rheumatoid Arthritis: An Overview