article Open AccessTop 1% cited
IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer
British Journal of Cancer · 2015 · Vol. 112(9) · pp. 1501–1509
Kaoru Abiko✉(Kyoto University)Noriomi Matsumura(Kyoto University)Junzo Hamanishi(Kyoto University)Naoki Horikawa(Kyoto University)Ryusuke Murakami(Kyoto University)Ken Yamaguchi(Kyoto University)Yumiko Yoshioka(Kyoto University)Tsukasa Baba(Kyoto University)Ikuo Konishi(Kyoto University)Masaki Mandai(Kindai University)
Abstract
Interferon-γ secreted by CD8-positive lymphocytes upregulates PD-L1 on ovarian cancer cells and promotes tumour growth. The lymphocyte infiltration and the IFN-γ status may be the key to effective anti-PD-1 or anti-PD-L1 therapy in ovarian cancer.
Cancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmune cells in cancerOvarian cancerCD8Cancer researchBiologyCytotoxic T cellInterferonCancerCancer cellImmunologyTumor-infiltrating lymphocytes
MeSH terms
AnimalsFemaleFlow CytometryHumansImmunoenzyme TechniquesInterferon-gammaMice, Inbred C57BLOvarian NeoplasmsPeritoneal NeoplasmsPrognosisTumor Cells, CulturedBlotting, WesternUp-RegulationLymphocytes, Tumor-InfiltratingApoptosis
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
Citations
699
FWCI
24.43
field-weighted impact
References
49
Percentile
100%
vs. same field & year
Citations per year
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Nature Communications · 2013 · 10,540 citations
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