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Metabolites from an Antarctic Sponge-Associated Bacterium, Pseudomonas aeruginosa

Journal of Natural Products · 1996 · Vol. 59(3) · pp. 293–296

Gamini S. Jayatilake✉(Florida Institute of Technology)Maureen Thornton(Florida Institute of Technology)Alan C. Leonard(Florida Institute of Technology)Julia E. Grimwade(Florida Institute of Technology)Bill J. Baker(Florida Institute of Technology)

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Abstract

In an ongoing survey of the bioactive potential of microorganisms associated with marine invertebrates, the culture media of a sponge-associated bacterial strain of Pseudomonas aeruginosa was found to contain metabolites which inhibit the growth of several Gram-positive microorganisms. A series of diketopiperazines (1-6) including a new natural product (6) and two known phenazine alkaloid antibiotics (7 and 8) were isolated from the culture broth of this bacterium.

Marine Sponges and Natural Products Microbial Natural Products and Biosynthesis Synthetic Organic Chemistry MethodsSpongePseudomonas aeruginosaPseudomonadaceaeBacteriaMicrobiologyPseudomonadalesBiologyChemistryBotanyGenetics

MeSH terms

AlkaloidsAnimalsAntarctic RegionsAnti-Bacterial AgentsBacteriaCulture MediaMicrobial Sensitivity TestsMagnetic Resonance SpectroscopyPiperazinesPoriferaPseudomonas aeruginosaSpectrometry, Mass, Fast Atom Bombardment

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Chaetopyranin, a Benzaldehyde Derivative, and Other Related Metabolites from Chaetomium globosum, an Endophytic Fungus Derived from the Marine Red Alga Polysiphonia urceolata