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The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine
Organic Letters · 2003 · Vol. 5(23) · pp. 4473–4475
Abstract
[reaction: see text] Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.
Catalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAlkyneChemistryAldehydeAmine gas treatingCatalysisComponent (thermodynamics)Coupling (piping)Combinatorial chemistryOrganic chemistry
Funding
- McGill University
Citations
454
FWCI
12.05
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References
16
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99%
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