article Open AccessTop 10% cited

B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease

American Journal Of Pathology · 2006 · Vol. 169(3) · pp. 987–998

Toshihisa KawaiTakashi Matsuyama(Kagoshima University)Yoshitaka HosokawaSeicho MakihiraMakoto Seki(Mitsubishi Group (Japan))Nadeem Y. Karimbux(Harvard University)Reginaldo Bruno GonçalvesPaloma Valverde(Tufts University)Serge Dibart(Boston University)Yiping LiLetícia Algarves MirandaCory W.O. ErnstYuichi Izumi(Kagoshima University)Martin A. Taubman✉

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Bone Metabolism and Diseases Bone health and treatments Oral microbiology and periodontitis researchRANKLOsteoclastOsteoprotegerinBone resorptionChemistryResorptionPeriodontitisReceptorCancer researchPathology

MeSH terms

B-LymphocytesBone ResorptionCarrier ProteinsCell DifferentiationCells, CulturedGene Expression RegulationGingivaGlycoproteinsHumansLymphocyte ActivationMembrane GlycoproteinsOsteoclastsPeriodontitisT-LymphocytesReceptors, Tumor Necrosis Factor

Funding

Amgen

Citations

553

FWCI

8.42

field-weighted impact

References

Percentile

98%

vs. same field & year

Citations per year

Cited by

Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints

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Inflammation and Bone Loss in Periodontal Disease

Journal of Periodontology · 2008 · 724 citations

References

Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1

Endocrinology · 1999 · 794 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

Cell · 1997 · 5,099 citations

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Endocrine Reviews · 1999 · 2,264 citations

RANK is essential for osteoclast and lymph node development

Genes & Development · 1999 · 1,484 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

Cell · 1998 · 5,439 citations

The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption

Journal of Bone and Mineral Research · 2000 · 1,181 citations

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