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A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

Bioorganic & Medicinal Chemistry Letters · 2002 · Vol. 12(3) · pp. 295–298

Chester A. Mathis✉(UPMC Health System)Brian J. Bacskai(Massachusetts General Hospital)Stephen T. Kajdasz(Massachusetts General Hospital)Megan E. McLellan(Massachusetts General Hospital)Matthew P. Frosch(Brigham and Women's Hospital)Bradley T. Hyman(Massachusetts General Hospital)Daniel P. Holt(University of Pittsburgh)Yanming Wang(University of Pittsburgh)Guo-Feng Huang(University of Pittsburgh)Manik L. Debnath(University of Pittsburgh)William E. Klunk(University of Pittsburgh)

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Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Neuroscience and Neuropharmacology ResearchThioflavinBenzothiazoleChemistryAmyloid (mycology)Positron emission tomographyGenetically modified mouseAlzheimer's diseaseBiophysicsBiochemistryTransgene

MeSH terms

Alzheimer DiseaseAmyloidAnimalsBinding, CompetitiveBrainChemistry, PhysicalMice, TransgenicMicroscopyStructure-Activity RelationshipThiazolesTomography, Emission-ComputedRadiopharmaceuticalsMiceBenzothiazolesChemical Phenomena

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Synthesis and Evaluation of <sup>11</sup>C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents