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Searching protein sequence libraries: Comparison of the sensitivity and selectivity of the Smith-Waterman and FASTA algorithms

Genomics · 1991 · Vol. 11(3) · pp. 635–650

William R. Pearson✉(University of Virginia)

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Genomics and Phylogenetic Studies Machine Learning in Bioinformatics RNA and protein synthesis mechanismsSmith–Waterman algorithmBiologySequence alignmentSequence databaseSimilarity (geometry)Protein sequencingSequence (biology)Multiple sequence alignmentSensitivity (control systems)Bioinformatics

MeSH terms

AlgorithmsAmino Acid SequenceMolecular Sequence DataProteinsSensitivity and SpecificitySoftwareGene LibraryDatabases, FactualInformation Storage and RetrievalSequence Alignment

Citations

585

FWCI

2.83

field-weighted impact

References

34

Percentile

92%

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References

Improved tools for biological sequence comparison.

Proceedings of the National Academy of Sciences · 1988 · 11,317 citations

Basic local alignment search tool

Journal of Molecular Biology · 1990 · 93,570 citations

An improved algorithm for matching biological sequences

Journal of Molecular Biology · 1982 · 1,751 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

Journal of Molecular Biology · 1970 · 11,386 citations

Identification of common molecular subsequences

Journal of Molecular Biology · 1981 · 10,021 citations

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