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The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

Acta Neuropathologica · 2013 · Vol. 126(4) · pp. 479–497
Patrick L. McGeerEdith G. McGeer
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsS100 Proteins and AnnexinsMicrogliaDiseaseNeurotoxicityInflammationBiomarkerPathogenesisMedicineAmyloid (mycology)Alzheimer's diseaseAmyloid beta

MeSH terms

Alzheimer DiseaseAmyloidAnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsDietHumansImmunizationInflammationMutationPeptide FragmentsBiomarkersAmyloid beta-PeptidesAmyloid beta-Protein Precursor
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References
Alzheimer’s Disease: The Challenge of the Second Century
Science Translational Medicine · 2011 · 1,414 citations
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Biochemical and Biophysical Research Communications · 1984 · 1,668 citations
The molecular pathology of Alzheimer's disease
Neuron · 1991 · 2,717 citations
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Proceedings of the National Academy of Sciences · 1985 · 4,412 citations
Neuropathological stageing of Alzheimer-related changes
Acta Neuropathologica · 1991 · 16,076 citations
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