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The colorectal adenoma–carcinoma sequence

British journal of surgery · 2002 · Vol. 89(7) · pp. 845–860

A Leslie✉(University of Dundee)F. A. CAREY(University of Dundee)Norman Pratt(Ninewells Hospital)R. Steele(University of Dundee)

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Abstract

Recent work continues to support the adenoma-carcinoma sequence, but there is a paucity of data on the interrelationship between different genetic mutations and on the relationship between molecular and other types of genetic abnormalities. The clinical utility of the observations described has yet to be fully realized and global genetic analysis of colorectal tumours may prove to be central in rational adenoma management.

Genetic factors in colorectal cancer Colorectal Cancer Treatments and Studies Colorectal Cancer Screening and DetectionMedicineAdenomaColorectal adenomaCytogeneticsCarcinomaSequence (biology)Colorectal cancerBioinformaticsPathologyComputational biology

MeSH terms

AdenomaCarcinomaCell Transformation, NeoplasticDNA RepairHumansKaryotypingMutationGenes, rasColorectal NeoplasmsGene ExpressionGenes, p53Gene DeletionMicrosatellite RepeatsDNA MethylationBase Pair Mismatch

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720

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8.60

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257

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