articleTop 10% cited

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

Experimental Neurology · 1999 · Vol. 158(2) · pp. 328–337

Jun Wang✉Dennis W. Dickson(Mayo Clinic in Florida)John Q. Trojanowski(University of Pennsylvania)Virginia M.‐Y. Lee(University of Pennsylvania)

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Alzheimer's disease research and treatments Cholinesterase and Neurodegenerative Diseases Prion Diseases and Protein MisfoldingAlzheimer's diseaseBrain agingAgeingEnzymeSenescenceAntibodyPathologyChemistryDiseaseBiology

MeSH terms

AgedAged, 80 and overAlzheimer DiseaseAntibodies, MonoclonalBrainBrain ChemistryEnzyme-Linked Immunosorbent AssayFemaleFluorescent DyesHumansMaleMiddle AgedPeptide FragmentsReference ValuesSolubility

Funding

Dana Foundation
National Institutes of Health
National Institute on Aging

Citations

563

FWCI

7.45

field-weighted impact

References

Percentile

98%

vs. same field & year

Citations per year

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References

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Neuron · 1994 · 1,756 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Neurology · 1992 · 2,673 citations

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Neurobiology of Aging · 1992 · 640 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Nature Medicine · 1996 · 2,586 citations

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