review Open AccessTop 10% cited
Force Generation by Microtubule Assembly/Disassembly in Mitosis and Related Movements
Molecular Biology of the Cell · 1995 · Vol. 6(12) · pp. 1619–1640
Shinya Inoué✉(Marine Biological Laboratory)Edward D. Salmon(University of North Carolina at Chapel Hill)
Abstract
In this article, we review the dynamic nature of the filaments (microtubules) that make up the labile fibers of the mitotic spindle and asters, we discuss the roles that assembly and disassembly of microtubules play in mitosis, and we consider how such assembling and disassembling polymer filaments can generate forces that are utilized by the living cell in mitosis and related movements.
Microtubule and mitosis dynamicsCellular Mechanics and InteractionsCardiomyopathy and Myosin StudiesMicrotubuleMitosisBiologyCell biologyAstral microtubulesSpindle apparatusBiophysicsCell divisionCellGenetics
MeSH terms
AnimalsHumansMicrotubulesMitosisModels, BiologicalModels, StructuralKinetochores
Citations
535
FWCI
9.88
field-weighted impact
References
160
Percentile
99%
vs. same field & year
Citations per year
Cited by
Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.
Molecular Biology of the Cell · 1997 · 482 citations
References
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
Molecular Biology of the Cell · 1992 · 963 citations
Cellular motions and thermal fluctuations: the Brownian ratchet
Biophysical Journal · 1993 · 892 citations
Cell Motility by Labile Association of Molecules
The Journal of General Physiology · 1967 · 759 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.