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Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

BMC Genomics · 2009 · Vol. 10(1) · pp. 556–556

Bok Sil Hong✉(Pohang University of Science and Technology)Ji‐Hoon Cho(Pohang University of Science and Technology)Hyun‐Jung Kim(Pohang University of Science and Technology)Eun-Jeong Choi(Pohang University of Science and Technology)Sangchul Rho(Pohang University of Science and Technology)Jongmin Kim(Pohang University of Science and Technology)Ji Hyun Kim(Pohang University of Science and Technology)Dongsic Choi(Pohang University of Science and Technology)Yoon‐Keun Kim(Pohang University of Science and Technology)Daehee Hwang(Pohang University of Science and Technology)Yong Song Gho(Pohang University of Science and Technology)

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Abstract

Our study demonstrates that CRC cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells, suggesting that microvesicles of cancer cells can be involved in tumor growth and metastasis by facilitating angiogenesis-related processes. This information will help elucidate the pathophysiological functions of tumor-derived microvesicles, and aid in the development of cancer diagnostics, including colorectal cancer.

Extracellular vesicles in disease Cancer-related molecular mechanisms research MicroRNA in disease regulationMicrovesiclesBiologyMicrovesicleAngiogenesisCell cycleCell biologyCancer cellCarcinogenesisColorectal cancermicroRNA

MeSH terms

Cell CycleHumansModels, BiologicalRNA, MessengerColorectal NeoplasmsGene Expression ProfilingEndothelial CellsCell Line, TumorCell ProliferationExosomes