article Open AccessTop 10% cited
Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
BMC Cancer · 2011 · Vol. 11(1) · pp. 130–130
Gali Soria✉(Tel Aviv University)Maya Ofri-Shahak(Tel Aviv University)Ilana Haas(Tel Aviv University)Neora Yaal‐Hahoshen(Tel Aviv University)Leonor Leider–Trejo(Tel Aviv University)Tal Leibovich-Rivkin(Tel Aviv University)Polina Weitzenfeld(Tel Aviv University)Tsipi Meshel(Tel Aviv University)Esther Shabtai(Tel Aviv University)Mordechai Gutman(Tel Aviv University)Adit Ben‐Baruch(Tel Aviv University)
Abstract
Our findings suggest that the coordinated expression of CCL2 & CCL5 and TNFα & IL-1β may be important for disease course, and that TNFα & IL-1β may promote disease relapse. Further in vitro and in vivo studies are needed for determination of the joint powers of the four factors in breast cancer, as well as analyses of their combined targeting in breast cancer.
Chemokine receptors and signalingCancer Cells and MetastasisImmunotherapy and Immune ResponsesCCL5ChemokineBreast cancerMedicineEpithelial–mesenchymal transitionCCL2Tumor necrosis factor alphaCancer researchMetastasisOncology
MeSH terms
AdultBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCell AdhesionCell MovementFemaleFlow CytometryHumansImmunohistochemistryMiddle AgedNeoplasm Recurrence, LocalTumor Necrosis Factor-alphaCarcinoma, Ductal, BreastMicroscopy, ConfocalInflammation Mediators
Funding
- Federico and Elvia Faggin Foundation
- Israel Science Foundation
Citations
280
FWCI
9.01
field-weighted impact
References
87
Percentile
99%
vs. same field & year
Citations per year
References
The inflammatory chemokines CCL2 and CCL5 in breast cancer
Cancer Letters · 2008 · 591 citations
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Nature reviews. Cancer · 2009 · 3,280 citations
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