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Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation

BMC Genomics · 2007 · Vol. 8(1) · pp. 70–70

Birgit Kulterer✉(Graz University of Technology)Gerald Friedl(Medical University of Graz)Anita JandrositzFátima Sánchez‐Cabo(Graz University of Technology)Andreas Prokesch(Graz University of Technology)Christine Paar(Graz University of Technology)Marcel Scheideler(Graz University of Technology)Reinhard Windhager(Medical University of Graz)Karl‐Heinz PreiseggerZlatko Trajanoski(Graz University of Technology)

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Abstract

With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications.

Mesenchymal stem cell research TGF-β signaling in diseases Osteoarthritis Treatment and MechanismsMesenchymal stem cellBiologyOsteoblastSMADCell biologyStem cellCellular differentiationGene expression profilingEx vivoBone marrow

MeSH terms

Bone Marrow CellsCell DifferentiationColony-Forming Units AssayHumansOsteoblastsOsteogenesisCluster AnalysisReverse Transcriptase Polymerase Chain ReactionOligonucleotide Array Sequence AnalysisGene Expression Profilingalpha-Crystallin B ChainInhibitor of Differentiation ProteinsMesenchymal Stem Cells

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GAGE: generally applicable gene set enrichment for pathway analysis