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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Cell Metabolism · 2009 · Vol. 10(3) · pp. 167–177

Charles Thomas✉(Centre National de la Recherche Scientifique)Antimo Gioiello(University of Perugia)Lilia G. Noriega(Centre National de la Recherche Scientifique)Axelle Strehle(Centre National de la Recherche Scientifique)Julien Oury(Centre National de la Recherche Scientifique)Giovanni Rizzo(Intercept Pharmaceuticals (United States))Antonio Macchiarulo(University of Perugia)Hiroyasu Yamamoto(Centre National de la Recherche Scientifique)Chikage Mataki(Centre National de la Recherche Scientifique)Mark Pruzanski(Intercept Pharmaceuticals (United States))Roberto Pellicciari(University of Perugia)Johan Auwerx(Centre National de la Recherche Scientifique)Kristina Schoonjans(Centre National de la Recherche Scientifique)

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Drug Transport and Resistance Mechanisms Pancreatic function and diabetes Diet and metabolism studiesBile acidG protein-coupled bile acid receptorHomeostasisGlucose homeostasisChemistryBiochemistryBiologyCell biologyEndocrinologyDiabetes mellitus

MeSH terms

Adenosine TriphosphateAnimalsBile Acids and SaltsCalciumCell LineCholic AcidsCricetulusGlucoseCricetinaeHomeostasisHumansInsulinMaleMice, Inbred C57BLMice, Obese

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Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy