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New insights into ubiquitin E3 ligase mechanism

Nature Structural & Molecular Biology · 2014 · Vol. 21(4) · pp. 301–307
Christopher BerndsenCynthia Wolberger
Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and TherapyUbiquitinUbiquitin ligaseUbiquitin-Protein LigasesDNA ligaseCell biologyChemistryUbiquitin-conjugating enzymeBiochemistryDeubiquitinating enzymeLysine

MeSH terms

CatalysisLysineModels, BiologicalSubstrate SpecificityUbiquitinsSignal TransductionUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesUbiquitination

Funding

  • National Science Foundation
  • National Institutes of Health
Citations
733
FWCI
26.48
field-weighted impact
References
87
Percentile
100%
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Citations per year
References
Breaking the chains: structure and function of the deubiquitinases
Nature Reviews Molecular Cell Biology · 2009 · 2,081 citations
RING Domain E3 Ubiquitin Ligases
Annual Review of Biochemistry · 2009 · 2,642 citations
The Ubiquitin Code
Annual Review of Biochemistry · 2012 · 3,574 citations
Structure of ubiquitin refined at 1.8 Å resolution
Journal of Molecular Biology · 1987 · 1,757 citations
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