article

Hypoglycemic Activity of Polypeptide-p From a Plant Source

Journal of Natural Products · 1981 · Vol. 44(6) · pp. 648–655

Pushpa Khanna✉S. C. JainA. PanagariyaV.P. Dixit

Abstract

A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.

Transgenic Plants and Applications Natural Antidiabetic Agents StudiesMomordicaBitter gourdPeptideAmino acidBiochemistryChemistryBiologyTraditional medicinePharmacologyMedicine

MeSH terms

AdolescentAdultAmino AcidsAnimalsCercopithecidaeCrystallizationDiabetes MellitusElectrophoresis, DiscFemaleGerbillinaeHumansHypoglycemic AgentsMaleMiddle AgedN-Glycosyl Hydrolases

Citations

287

FWCI

0.31

field-weighted impact

References

Percentile

56%

vs. same field & year

Citations per year

Cited by

Leads from Indian medicinal plants with hypoglycemic potentials