article

Monofluoro- and difluoro-methylenebisphosphonic acids: isopolar analogues of pyrophosphoric acid

Journal of the Chemical Society Chemical Communications · 1981 · pp. 930–930

G. Michael Blackburn✉David A. EnglandFriedrich Kolkmann

Abstract

New syntheses are described for the preparation of monofluoromethylenebisphosphonic and difluoromethylenebisphosphonic acids whose physical properties show them to be good isopolar analogues of pyrophosphoric acid of significant biological potential.

Fluorine in Organic Chemistry Bone health and treatments Radiopharmaceutical Chemistry and ApplicationsChemistryBiochemistry

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248

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2.72

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