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Novel Antiviral Fucoidan from Sporophyll of Undaria pinnatifida (Mekabu)

Chemical and Pharmaceutical Bulletin · 2004 · Vol. 52(9) · pp. 1091–1094

Jung‐Bum Lee✉(Tohoku Medical and Pharmaceutical University)Kyoko Hayashi(Tohoku Medical and Pharmaceutical University)Minoru HASHIMOTOTakahisa NakanoToshimitsu Hayashi(Tohoku Medical and Pharmaceutical University)

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Abstract

Structural characterization and antiviral activities of fucoidan from sporophyll of Undaria pinnatifida (Mekabu) was examined. The fucoidan was composed of fucose and galactose with an approximately ratio of 1.0:1.1. Degree of substitution of sulfate was 0.72 and its apparent molecular weight was 9,000. Methylation analyses showed that fucoidan had various sugar linkages, and revealed that the fucoidan might have complicated structure. This fucoidan showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus.

Seaweed-derived Bioactive Compounds Polysaccharides and Plant Cell Walls Microbial Metabolites in Food BiotechnologyFucoidanFucoseChemistryGalactosePolysaccharideBiochemistry

MeSH terms

AnimalsAntiviral AgentsCell LineCytomegalovirusEnterovirusInfluenza A virusPolysaccharidesPoliovirusHerpesvirus 2, HumanHerpesvirus 1, HumanInhibitory Concentration 50Undaria

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271

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11.66

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Fucoidan: Structure and Bioactivity