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Long‐term effects of androgen deprivation therapy in prostate cancer patients

Clinical Endocrinology · 2002 · Vol. 56(6) · pp. 779–786

Shehzad Basaria✉John LiebAlice Tang(Tufts University)Theodore L. DeWeese(Radiation Oncology Associates)Michael A. Carducci(Johns Hopkins Medicine)Mario A. Eisenberger(Johns Hopkins Medicine)Adrian S. Dobs

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Abstract

This study suggests that osteoporosis, unfavourable body composition, sexual dysfunction and reduced quality of life are seen in patients receiving androgen deprivation therapy for at least 12 months. Longitudinal studies in this patient population will shed further light on the timing of the development and the extent of these complications. Meanwhile, this information will assist both physicians and patients with prostate cancer to make informed decisions regarding androgen deprivation therapy.

Prostate Cancer Treatment and Research Hormonal and reproductive studies Estrogen and related hormone effectsMedicineAndrogen deprivation therapyProstate cancerInternal medicineCastrationTestosterone (patch)UrologyEndocrinologyCancerHormone

MeSH terms

AgedAndrogen AntagonistsBody CompositionCollagenCross-Sectional StudiesHumansErectile DysfunctionMalePeptidesProstatic NeoplasmsQuality of LifeTestosteroneBone DensityCase-Control StudiesAntineoplastic Agents, Hormonal