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Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

Cardiovascular Research · 2014 · Vol. 103(4) · pp. 530–541

Lucio Barile✉(Epatocentro Ticino)Vincenzo Lionetti(Scuola Superiore Sant'Anna)Elisabetta Cervio(Epatocentro Ticino)Marco Matteucci(Scuola Superiore Sant'Anna)Mihaela Gherghiceanu(Institutul National Victor Babes)Laurenţiu M. Popescu(Institutul National Victor Babes)Tiziano Torre(Epatocentro Ticino)Francesco Siclari(Epatocentro Ticino)Tiziano Moccetti(Epatocentro Ticino)Giuseppe Vassalli(University Hospital of Lausanne)

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Abstract

EVs are the active component of the paracrine secretion by human CPCs. As a cell-free approach, EVs could circumvent many of the limitations of cell transplantation.

Extracellular vesicles in disease MicroRNA in disease regulation Cardiovascular Disease and AdiposityMicrovesiclesParacrine signallingCell biologyUmbilical veinExosomeApoptosisAngiogenesisMyocyteCardiac function curveSecretion

MeSH terms

AnimalsCell DifferentiationCells, CulturedExtracellular SpaceHumansMaleMyocardial InfarctionStem CellsCulture Media, ConditionedRats, WistarApoptosisMyocytes, CardiacMicroRNAsMice

Funding

National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Schweizerische Herzstiftung
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
Scuola Superiore Sant'Anna

Citations

713

FWCI

24.06

field-weighted impact

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100%

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Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization