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Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

Journal of Neurology Neurosurgery & Psychiatry · 2011 · Vol. 82(7) · pp. 740–746

Adriano Chiò✉(Neuroscience Institute)Andrea Calvo(Azienda Ospedaliero Universitaria San Giovanni Battista)Cristina Moglia(Azienda Ospedaliero Universitaria San Giovanni Battista)Letizia Mazzini(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”)Gabriele Mora(Fondazione Salvatore Maugeri)PARALS study group

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Abstract

Our epidemiological findings suggest that ALS phenotypes carry distinctive and easily distinguishable clinical and prognostic characteristics, strongly related to a complex interplay between gender and age. The categorisation of ALS patients according to more homogenous clinical groups is relevant in identifying biological markers for ALS and should be considered for the design of clinical trials.

Amyotrophic Lateral Sclerosis Research Neurogenetic and Muscular Disorders Research Neurological diseases and metabolismAmyotrophic lateral sclerosisPhenotypeIncidence (geometry)EpidemiologyPopulationMedicineUpper motor neuronInternal medicineBiologyDisease

MeSH terms

Age FactorsAgedAmyotrophic Lateral SclerosisDysarthriaFemaleHumansMaleMiddle AgedMotor NeuronsPhenotypeRegistriesSex FactorsSurvivalTracheostomyRespiratory Mechanics

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601

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14.78

field-weighted impact

References

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99%

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References

El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis