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Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship

Bioorganic & Medicinal Chemistry · 2004 · Vol. 12(21) · pp. 5571–5578
Marek MuriasNorbert HandlerThomas ErkerKarin PlebanGerhard F. EckerPhilipp SaikoThomas SzekeresWalter Jäger
Inflammatory mediators and NSAID effectsComputational Drug Discovery MethodsSynthesis and biological activityChemistryResveratrolCyclooxygenaseEnzymeStereochemistrySelectivityEnzyme inhibitorDocking (animal)Structure–activity relationshipIn vitro

MeSH terms

ResveratrolAnimalsHumansMembrane ProteinsModels, MolecularProstaglandin-Endoperoxide SynthasesSheepStilbenesStructure-Activity RelationshipCyclooxygenase InhibitorsProtein Structure, SecondaryCyclooxygenase 2Cyclooxygenase 2 Inhibitors

Funding

  • European Commission
Citations
284
FWCI
9.01
field-weighted impact
References
33
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98%
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Cited by
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References
Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking
Proteins Structure Function and Bioinformatics · 1999 · 894 citations
The Protein Data Bank
Nucleic Acids Research · 2000 · 39,191 citations
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