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Do Surgical Patients Benefit from Perioperative Gabapentin/Pregabalin? A Systematic Review of Efficacy and Safety
Anesthesia & Analgesia · 2007 · Vol. 104(6) · pp. 1545–1556
Elina Tiippana✉(Helsinki University Hospital)Katri Hamunen✉(Helsinki University Hospital)Vesa Kontinen✉(University of Helsinki)Eija Kalso✉(Helsinki University Hospital)
Abstract
Gabapentinoids effectively reduce postoperative pain, opioid consumption, and opioid-related adverse effects after surgery. Conclusions about the optimal dose and duration of the treatment cannot be made because of the heterogeneity of the trials. Studies are needed to determine the long-term benefits, if any, of perioperative gabapentinoids.
Anesthesia and Pain ManagementPain Management and Opioid UseAnesthesia and Sedative AgentsGabapentinMedicinePregabalinAdverse effectAnesthesiaNeuropathic painPerioperativeRandomized controlled trialAnalgesicOpioid
MeSH terms
PregabalinGabapentinAminesCyclohexanecarboxylic AcidsDizzinessgamma-Aminobutyric AcidHumansPain, PostoperativePostoperative PainRandomized Controlled Trials as TopicPerioperative Care
Citations
529
FWCI
27.11
field-weighted impact
References
61
Percentile
100%
vs. same field & year
Citations per year
References
Pregabalin Pharmacology and Its Relevance to Clinical Practice
Epilepsia · 2004 · 533 citations
Advances in Neuropathic Pain
Archives of Neurology · 2003 · 1,205 citations
Chronic Pain as an Outcome of Surgery
Anesthesiology · 2000 · 1,332 citations
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