article Open AccessTop 10% cited
From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
Bioorganic & Medicinal Chemistry Letters · 2007 · Vol. 17(21) · pp. 6013–6018
Brian Springthorpe✉(AstraZeneca (Singapore))A. S. Bailey(Loughborough University)Patrick Barton(AstraZeneca (United Kingdom))Timothy N. Birkinshaw(AstraZeneca (United Kingdom))Roger V. Bonnert(Loughborough University)Roger C. Brown(Loughborough University)David A. Chapman(Loughborough University)John Dixon(Loughborough University)Simon D. Guile(Loughborough University)Robert G. Humphries(AstraZeneca (United Kingdom))Simon F. Hunt(AstraZeneca (United Kingdom))Francis Ince(AstraZeneca (United Kingdom))Anthony H. Ingall(AstraZeneca (United Kingdom))Ian P. Kirk(Loughborough University)Paul D. Leeson(AstraZeneca (United Kingdom))Paul Leff(AstraZeneca (United Kingdom))Richard J. Lewis(Loughborough University)Barrie Martin(Loughborough University)Dermot F. McGinnity(Loughborough University)Michael P. Mortimore(Loughborough University)Stuart W. Paine(Loughborough University)Garry Pairaudeau(Loughborough University)Anil S. Patel(AstraZeneca (United Kingdom))Aaron Rigby(Loughborough University)Robert J. Riley(Loughborough University)Barry Teobald(AstraZeneca (United Kingdom))Wendy Tomlinson(AstraZeneca (United Kingdom))Peter J. H. Webborn(AstraZeneca (United Kingdom))Paul Willis(AstraZeneca (United Kingdom))
Antiplatelet Therapy and Cardiovascular DiseasesSynthesis of β-Lactam CompoundsAcute Myocardial Infarction ResearchChemistryP2Y12AntagonistPharmacologyPurineReceptorAdenosine triphosphateThrombosisBiochemistryStereochemistry
MeSH terms
TicagrelorAdenosineAdenosine TriphosphateAdministration, OralAnimalsHumansMembrane ProteinsThrombosisPurinergic P2 Receptor AntagonistsReceptors, Purinergic P2Y12
Citations
233
FWCI
6.24
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References
15
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97%
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References
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
The Lancet · 1996 · 6,493 citations
Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation
New England Journal of Medicine · 2001 · 6,459 citations
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