articleTop 10% cited
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies
Bioorganic & Medicinal Chemistry · 2006 · Vol. 14(9) · pp. 3160–3173
Ramy Farid✉(Schrodinger (United States))Tyler Day(Schrodinger (United States))Richard A. Friesner(Columbia University)Robert A. Pearlstein(Schrodinger (United States))
Cardiac electrophysiology and arrhythmiasIon channel regulation and functionProtein Structure and DynamicsChemistryDocking (animal)hERGHomology modelingHydrophobic effectStereochemistryMolecular dynamicsCrystallographyPotassium channelBiophysics
MeSH terms
Models, MolecularMolecular Sequence DataSequence AlignmentConserved SequenceSequence Homology, Amino AcidProtein Structure, QuaternaryPotassium Channel BlockersStructural Homology, ProteinEther-A-Go-Go Potassium ChannelsHydrophobic and Hydrophilic Interactions
Citations
502
FWCI
7.44
field-weighted impact
References
40
Percentile
98%
vs. same field & year
Citations per year
Cited by
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Journal of Medicinal Chemistry · 2006 · 6,738 citations
References
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
Journal of Medicinal Chemistry · 2004 · 9,717 citations
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
Journal of Medicinal Chemistry · 2004 · 5,119 citations
Highly Accurate Coupled Cluster Potential Energy Curves for the Benzene Dimer: Sandwich, T-Shaped, and Parallel-Displaced Configurations
The Journal of Physical Chemistry A · 2004 · 704 citations
A hierarchical approach to all‐atom protein loop prediction
Proteins Structure Function and Bioinformatics · 2004 · 2,486 citations
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