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The Biologic Clock: The Mitochondria?

Journal of the American Geriatrics Society · 1972 · Vol. 20(4) · pp. 145–147
Denham Harman

Abstract

ABSTRACT: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsBirth, Development, and HealthMedicineMitochondrionLife spanOxygenMitochondrial DNAMortality rateCell biologyBiochemistryGerontologyGene

MeSH terms

AgingAnimalsAntioxidantsBasal MetabolismBiological ClocksFree RadicalsLife ExpectancyMitochondriaOxidative PhosphorylationOxygen ConsumptionMice
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