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A systematic meta‐analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft‐tissue sarcoma

Cancer · 2008 · Vol. 113(3) · pp. 573–581

N. Pervaiz(University of Waterloo)Nigel Colterjohn(Hamilton Health Sciences)Forough Farrokhyar(Juravinski Cancer Centre)Richard Tozer(McMaster University)A Figueredo(Juravinski Cancer Centre)Michelle Ghert✉(Juravinski Cancer Centre)

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Abstract

This updated meta-analysis confirms the marginal efficacy of chemotherapy in localized resectable soft-tissue sarcoma with respect to local recurrence, distant recurrence, overall recurrence, and overall survival. These benefits are further improved with the addition of ifosfamide to doxorubicin-based regimens, but must be weighed against associated toxicities.

Sarcoma Diagnosis and Treatment Vascular Tumors and Angiosarcomas Vascular Malformations and HemangiomasMedicineSoft tissue sarcomaIfosfamideChemotherapySarcomaDoxorubicinOncologyRandomized controlled trialMeta-analysisInternal medicine

MeSH terms

AlgorithmsAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyDoxorubicinHumansNeoplasm MetastasisNeoplasm Recurrence, LocalSarcomaOdds RatioSurvival AnalysisRandomized Controlled Trials as TopicChemotherapy, Adjuvant

Citations

967

FWCI

26.29

field-weighted impact

References

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100%

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Cited by

Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Annals of Oncology · 2018 · 1,598 citations

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