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Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
Cardiovascular Research · 1999 · Vol. 43(4) · pp. 985–991
Wendy S. Post✉(Johns Hopkins University)
Abstract
Methylation associated inactivation of the ER alpha gene in vascular tissue may play a role in atherogenesis and aging of the vascular system. This potentially reversible defect may provide a new target for intervention in heart disease.
Estrogen and related hormone effectsMenopause: Health Impacts and TreatmentsNuclear Receptors and SignalingMethylationDNA methylationEstrogen receptor alphaVascular smooth muscleEstrogen receptorBiologyEndocrinologyInternal medicineAortaGene expression
MeSH terms
AgingAortaCardiovascular SystemCells, CulturedCoronary DiseaseEndothelium, VascularFemaleHeart AtriaHumansMaleMammary ArteriesMiddle AgedMuscle, Smooth, VascularReceptors, EstrogenSaphenous Vein
Citations
481
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8.43
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30
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98%
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References
Cloning of a novel receptor expressed in rat prostate and ovary.
Proceedings of the National Academy of Sciences · 1996 · 4,791 citations
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