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Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity

Journal of Controlled Release · 2002 · Vol. 83(2) · pp. 273–286
Cristina FonsecaSérgio SimõesRogério Gaspar
Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsPaclitaxelPLGAViability assayNanoparticleIn vitroChemistryDrug deliveryGlycolic acidPharmacologyCytotoxicity

MeSH terms

Polylactic Acid-Polyglycolic Acid CopolymerChemistry, PhysicalDrug Screening Assays, AntitumorHumansPolyglycolic AcidPolymersTumor Cells, CulturedDrug Delivery SystemsPaclitaxelLactic AcidNanotechnologyChemical Phenomena
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740
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9.16
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68
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99%
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References
Paclitaxel
Drugs · 1994 · 394 citations
Biodegradation and biocompatibility of PLA and PLGA microspheres
Advanced Drug Delivery Reviews · 1997 · 2,576 citations
Nanocapsule formation by interfacial polymer deposition following solvent displacement
International Journal of Pharmaceutics · 1989 · 2,187 citations
Cremophor EL
European Journal of Cancer · 2001 · 1,626 citations
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