article
The NK model of rugged fitness landscapes and its application to maturation of the immune response
Journal of Theoretical Biology · 1989 · Vol. 141(2) · pp. 211–245
Stuart Kauffman✉(University of Pennsylvania)Edward D. Weinberger(University of Pennsylvania)
Monoclonal and Polyclonal Antibodies ResearchEvolution and Genetic DynamicsT-cell and B-cell ImmunologyFitness landscapeSomatic hypermutationBiologyAffinity maturationImmune systemProperty (philosophy)Sequence spaceComputational biologyFunction (biology)Mutant
MeSH terms
Amino Acid SequenceAnimalsAntigensImmunityImmunoglobulin Constant RegionsImmunoglobulin Variable RegionKiller Cells, NaturalLymphocyte ActivationModels, TheoreticalMolecular Sequence DataMutationSelection, Genetic
Citations
678
FWCI
1.07
field-weighted impact
References
74
Percentile
78%
vs. same field & year
Citations per year
References
Towards a general theory of adaptive walks on rugged landscapes
Journal of Theoretical Biology · 1987 · 1,416 citations
Spin glasses: Experimental facts, theoretical concepts, and open questions
Reviews of Modern Physics · 1986 · 5,107 citations
Solvable Model of a Spin-Glass
Physical Review Letters · 1975 · 4,214 citations
Strategies for epitope analysis using peptide synthesis
Journal of Immunological Methods · 1987 · 871 citations
The theory of games and the evolution of animal conflicts
Journal of Theoretical Biology · 1974 · 2,441 citations
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