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A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

The American Journal of Human Genetics · 2011 · Vol. 89(1) · pp. 168–175

Alexander Zimprich✉(Medical University of Vienna)Anna Benet‐Pagès(Helmholtz Zentrum München)Walter Struhal(Krankenhaus der Elisabethinen)Elisabeth Graf(Helmholtz Zentrum München)Sebastian Eck(Helmholtz Zentrum München)Marc N. Offman(Technical University of Munich)Dietrich Haubenberger(Medical University of Vienna)Sabine Spielberger(Innsbruck Medical University)Eva C. Schulte(Technical University of Munich)Peter Lichtner(Helmholtz Zentrum München)Shaila C. Rössle(Technical University of Munich)Norman Klopp(Helmholtz Zentrum München)Elisabeth Wolf(Innsbruck Medical University)Klaus Seppi(Innsbruck Medical University)Walter Pirker(Medical University of Vienna)Stefan Presslauer(Wilhelminen Hospital)Brit Mollenhauer(Paracelsus Elena Klinik Kassel)Regina Katzenschlager(Donauspital)Thomas Foki(Medical University of Vienna)Christoph Hotzy(Medical University of Vienna)Eva M. Reinthaler(Medical University of Vienna)Ashot S. Harutyunyan(Austrian Academy of Sciences)Róbert Královics(Austrian Academy of Sciences)Annette Peters(Helmholtz Zentrum München)Fritz Zimprich(Medical University of Vienna)Thomas Brücke(Wilhelminen Hospital)Werner Poewe(Innsbruck Medical University)Eduard Auff(Medical University of Vienna)Claudia Trenkwalder(University of Göttingen)Burkhard Rost(Technical University of Munich)Gerhard Ransmayr(Krankenhaus der Elisabethinen)Juliane Winkelmann(Technical University of Munich)Thomas Meitinger(Technical University of Munich)Tim M. Strom✉(Technical University of Munich)

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Parkinson's Disease Mechanisms and Treatments Neurological diseases and metabolism Neurological disorders and treatmentsRetromerParkinson's diseaseProtein subunitMutationDiseaseGeneticsBiologyMedicineEndosomeGene

MeSH terms

AdultAgedAged, 80 and overFemaleHaplotypesHumansHydrogen BondingMaleMiddle AgedParkinson DiseasePedigreeProtein ConformationEndosomesGenetic VariationCohort Studies

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