article Open AccessTop 1% cited
Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease
Alimentary Pharmacology & Therapeutics · 2014 · Vol. 40(10) · pp. 1209–1222
Larysa Fedchuk(Pitié-Salpêtrière Hospital)Fabio Nascimbeni(University of Modena and Reggio Emilia)R. Pais(Pitié-Salpêtrière Hospital)Frédéric Charlotte(Pitié-Salpêtrière Hospital)Chantal HoussetVlad Ratziu✉(Sorbonne Université)the LIDO Study Group
Abstract
All five steatosis biomarkers can diagnose steatosis and are correlated with insulin resistance. They are confounded by fibrosis and inflammation, and do not accurately quantify steatosis; this may limit their clinical utility. More research is needed to identify truly independent and quantitative markers of steatosis.
Liver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseCardiovascular Function and Risk FactorsNonalcoholic fatty liver diseaseSteatosisMedicineLiver steatosisFatty liverInternal medicineGastroenterologyDiseaseNonalcoholic steatohepatitis
MeSH terms
BiopsyBlood GlucoseFatty LiverFemaleHumansInflammationInsulin ResistanceLiverLiver CirrhosisMaleMiddle AgedTriglyceridesBiomarkersAdiposity
Funding
- Directorate-General for Research and Innovation
Citations
504
FWCI
13.51
field-weighted impact
References
57
Percentile
99%
vs. same field & year
Citations per year
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References
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The Product of Triglycerides and Glucose, a Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic-Hyperinsulinemic Clamp
The Journal of Clinical Endocrinology & Metabolism · 2010 · 2,160 citations
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The Lancet · 2005 · 9,222 citations
Visceral Adiposity Index
Diabetes Care · 2010 · 1,689 citations
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