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Semiconductor Nanocrystals as Fluorescent Biological Labels

Science · 1998 · Vol. 281(5385) · pp. 2013–2016

Marcel P. Bruchez(Lawrence Berkeley National Laboratory)Mario M. Moronne(Lawrence Berkeley National Laboratory)Peter Gin(Lawrence Berkeley National Laboratory)Shimon Weiss✉(Lawrence Berkeley National Laboratory)A. Paul Alivisatos✉(Lawrence Berkeley National Laboratory)

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Abstract

Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.

Quantum Dots Synthesis And Properties Advanced biosensing and bioanalysis techniques Nanocluster Synthesis and ApplicationsNanocrystalFluorescenceSemiconductorMaterials scienceOptoelectronicsExcitationBroad spectrumNanotechnologyChemistryOptics

MeSH terms

ActinsAnimalsCell NucleusCrystallizationCytoskeletonFluorescent DyesMicroscopy, FluorescenceSemiconductorsSilicon DioxideSolubilitySpectrometry, FluorescenceStaining and LabelingSulfidesMolecular Probe Techniques3T3 Cells

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