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RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy

American Journal Of Pathology · 2003 · Vol. 162(4) · pp. 1123–1137
Thoralf WendtNozomu TanjiJiancheng GuoThomas KislingerWu QuYan LüLoredana BucciarelliLing RongBernhard MoserGlen S. MarkowitzG SteinAngelika BierhausBirgit LiliensiekBernd ArnoldPeter P. NawrothDavid M. SternVivette D. D’AgatiAnn Marie Schmidt
Advanced Glycation End Products researchChronic Kidney Disease and DiabetesNeonatal Respiratory Health ResearchPodocyteGlomerulosclerosisPathogenesisDiabetic nephropathyRage (emotion)MedicineDiabetes mellitusNeuroscienceImmunologyEndocrinology

MeSH terms

Receptor for Advanced Glycation End ProductsAlbuminuriaAnimalsCell DifferentiationCells, CulturedDiabetic NephropathiesDisease Models, AnimalKidney CortexMaleMice, Mutant StrainsReceptors, ImmunologicGlycation End Products, AdvancedDisease ProgressionUrotheliumMice

Funding

  • Deutsche Forschungsgemeinschaft
Citations
589
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References
End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
American Journal of Kidney Diseases · 1999 · 799 citations
Secretory products of macrophages.
Journal of Clinical Investigation · 1987 · 2,642 citations
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
American Journal of Physiology-Endocrinology and Metabolism · 2001 · 1,042 citations
The S100 family of EF-hand calcium-binding proteins: functions and pathology
Trends in Biochemical Sciences · 1996 · 1,005 citations
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