articleTop 10% cited
Gender Differences in Pharmacokinetics of Alcohol
Alcoholism Clinical and Experimental Research · 2001 · Vol. 25(4) · pp. 502–507
Enrique Baraona(Veterans Health Administration)Chaim S. Abittan(Icahn School of Medicine at Mount Sinai)Kazufumi Dohmen(Icahn School of Medicine at Mount Sinai)Michelle Moretti(Icahn School of Medicine at Mount Sinai)Gabriele Pozzato(Icahn School of Medicine at Mount Sinai)Zev W. Chayes(Icahn School of Medicine at Mount Sinai)Clara Schaefer(Icahn School of Medicine at Mount Sinai)Charles S. Lieber✉(Icahn School of Medicine at Mount Sinai)
Abstract
The gender difference in alcohol levels is due mainly to a smaller gastric metabolism in females (because of a significantly lesser activity of chi-ADH), rather than to differences in gastric emptying or in hepatic oxidation of ethanol. The concentration-dependency of these effects may explain earlier discrepancies. The combined pharmacokinetic differences may increase the vulnerability of women to the effects of ethanol.
Alcohol Consumption and Health EffectsDiet and metabolism studiesLiver Disease Diagnosis and TreatmentAcetaldehydeAlcoholAlcohol dehydrogenaseEthanolPharmacokineticsEthanol metabolismChemistryGastric emptyingVolume of distributionToxicity
MeSH terms
AdultAlcohol DehydrogenaseEthanolAldehyde OxidoreductasesCentral Nervous System DepressantsFemaleGastric EmptyingGastric MucosaHumansMaleSex FactorsStatistics, NonparametricArea Under Curve
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Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations
Drug and Alcohol Dependence · 2015 · 1,013 citations
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