articleTop 1% cited

Proteasomal function is impaired in substantia nigra in Parkinson's disease

Neuroscience Letters · 2001 · Vol. 297(3) · pp. 191–194

Kevin St. P. McNaught(King's College London)Peter Jenner✉(King's College London)

Parkinson's Disease Mechanisms and Treatments Neurological diseases and metabolism Cellular transport and secretionSubstantia nigraProteasomeParkinson's diseaseDopaminergicLewy bodyDopamineAlpha-synucleinUbiquitinNeuroscienceDegenerative disease

MeSH terms

AcetylcysteineAgedCysteine EndopeptidasesDihydroxyphenylalanineEnzyme ActivationEnzyme InhibitorsFemaleHumansHydrolysisLevodopaMaleMultienzyme ComplexesParkinson DiseasePeptide HydrolasesProtein Processing, Post-Translational

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646

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References

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Annals of Neurology · 1994 · 1,146 citations

Impaired Proteasome Function in Alzheimer's Disease

Journal of Neurochemistry · 2000 · 833 citations

Anatomic and Disease Specificity of NADH CoQ<sub>1</sub> Reductase (Complex I) Deficiency in Parkinson's Disease

Journal of Neurochemistry · 1990 · 678 citations

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Nature Genetics · 1998 · 3,865 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Science · 1997 · 8,181 citations

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