articleTop 10% cited

Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate

Movement Disorders · 1991 · Vol. 6(4) · pp. 288–292

Tipu Z. Aziz✉(University of Manchester)David Peggs(University of Manchester)M.A. Sambrook(University of Manchester)Alan R. Crossman(University of Manchester)

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Abstract

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

Neurological disorders and treatments Parkinson's Disease Mechanisms and Treatments Neuroscience and Neuropharmacology ResearchMPTPSubthalamic nucleusParkinsonismLesionNucleusNeuroscienceParkinson's diseaseMedicinePsychologyPathology

MeSH terms

AnimalsBrain MappingDominance, CerebralMacaca fascicularisNeurologic ExaminationParkinson Disease, SecondaryThalamic Nuclei1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineRadiosurgery

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536

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10.06

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Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease