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Pharmacokinetics and Pharmacodynamics of a Sustained-Release Dexamethasone Intravitreal Implant
Investigative Ophthalmology & Visual Science · 2010 · Vol. 52(1) · pp. 80–80
Joan-En Chang-Lin✉(Allergan (United States))Mayssa Attar(Allergan (United States))Andrew Acheampong(Allergan (United States))Michael R. Robinson(Allergan (United States))Scott M. Whitcup(Allergan (United States))Baruch D. KuppermannDevin Welty(Allergan (United States))
Abstract
The in vivo release profile of the DEX implant in an animal eye was similar to the pharmacokinetics achieved with pulse administration of corticosteroids (high initial drug concentration, followed by a prolonged period of low concentration). These results are consistent with those in clinical studies supporting the use of the DEX implant for the extended management of posterior segment diseases.
Retinal Diseases and TreatmentsGlaucoma and retinal disordersIntraocular Surgery and LensesPharmacokineticsDexamethasoneImplantPharmacodynamicsMedicineIn vivoRetinaChemistryPharmacologyEndocrinology
MeSH terms
AnimalsBiological AvailabilityChromatography, High Pressure LiquidDelayed-Action PreparationsDexamethasoneDrug ImplantsGlucocorticoidsHalf-LifeMacaca fascicularisMaleRetinaTissue DistributionVitreous BodyGene Expression Regulation, EnzymologicArea Under Curve
Citations
583
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19.40
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48
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100%
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Cited by
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Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion
Ophthalmology · 2010 · 1,061 citations
A new mathematical model for relative quantification in real-time RT-PCR
Nucleic Acids Research · 2001 · 34,549 citations
Glucocorticoids and Cardiovascular Disease
European Journal of Endocrinology · 2007 · 525 citations
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