articleTop 1% cited
The GABAergic deficit hypothesis of major depressive disorder
Molecular Psychiatry · 2010 · Vol. 16(4) · pp. 383–406
Bernhard Lüscher✉(Pennsylvania State University)Shen Qu(Pennsylvania State University)Nadia Sahir(Pennsylvania State University)
Neuroscience and Neuropharmacology ResearchTryptophan and brain disordersStress Responses and CortisolMonoaminergicGABAergicNeuroscienceGABAA receptorPsychologyHippocampusgamma-Aminobutyric acidMedicineInhibitory postsynaptic potentialReceptor
MeSH terms
AnimalsAntidepressive AgentsBrainDepressive Disorder, MajorMajor Depressive DisorderDisease Models, Animalgamma-Aminobutyric AcidGene Expression RegulationHumansMutationRisk FactorsReceptors, GABAGenetic Predisposition to DiseaseMice
Funding
- Pennsylvania Department of Health
Citations
923
FWCI
10.34
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395
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99%
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Anxiety and affective style: role of prefrontal cortex and amygdala
Biological Psychiatry · 2002 · 1,125 citations
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
Molecular Psychiatry · 2002 · 1,254 citations
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