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Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy
New England Journal of Medicine · 2001 · Vol. 345(12) · pp. 861–869
Barry M. Brenner✉(Brigham and Women's Hospital)Mark E. Cooper(University of Melbourne)Dick de Zeeuw(University of Groningen)William F. Keane(Hennepin County Medical Center)William E. Mitch(Emory University)Hans‐Henrik Parving(Steno Diabetes Center)Giuseppe Remuzzi(Mario Negri Institute for Pharmacological Research)Steven Snapinn(Merck & Co., Inc., Rahway, NJ, USA (United States))Zhonxin Zhang(Merck & Co., Inc., Rahway, NJ, USA (United States))Shahnaz Shahinfar(Merck & Co., Inc., Rahway, NJ, USA (United States))
Abstract
Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesChronic Kidney Disease and DiabetesMedicineLosartanInternal medicineDiabetic nephropathyNephropathyDiabetes mellitusType 2 diabetesCreatinineKidney diseaseBlood pressure
MeSH terms
AdultAgedAntihypertensive AgentsCardiovascular DiseasesCreatineCreatinineDiabetes Mellitus, Type 2Diabetic NephropathiesDouble-Blind MethodFemaleHumansHypertensionKidney Failure, ChronicMaleMiddle Aged
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38
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