articleTop 1% cited
Metformin in the treatment of non‐alcoholic steatohepatitis: a pilot open label trial
Alimentary Pharmacology & Therapeutics · 2004 · Vol. 20(1) · pp. 23–28
Satheesh Nair✉(Ochsner Medical Center)Anna Mae Diehl(Johns Hopkins University)Mark Wiseman(Ochsner Medical Center)Gist H. Farr(Ochsner Medical Center)Robert P. Perrillo(Ochsner Medical Center)
Abstract
Metformin treatment was associated with only a transient improvement in liver chemistries. A progressive, sustainable reduction in insulin sensitivity was not noted during treatment.
Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and CancerPancreatitis Pathology and TreatmentMedicineMetforminInsulin resistanceSteatohepatitisInternal medicineFatty liverGastroenterologySteatosisLiver biopsyInsulin
MeSH terms
Alanine TransaminaseAspartate AminotransferasesDrug EvaluationFemaleHepatitisHumansHypoglycemic AgentsInsulin ResistanceMaleMetforminMiddle AgedPatient CompliancePilot ProjectsTreatment Outcome
Citations
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Role of AMP-activated protein kinase in mechanism of metformin action
Journal of Clinical Investigation · 2001 · 5,364 citations
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