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Hippocampal and Entorhinal Cortex High‐Frequency Oscillations (100–500 Hz) in Human Epileptic Brain and in Kainic Acid‐Treated Rats with Chronic Seizures

Epilepsia · 1999 · Vol. 40(2) · pp. 127–137

Anatol Bragin✉(University of California, Los Angeles)Jerome Engel(University of California, Los Angeles)Charles L. Wilson(University of California, Los Angeles)Itzhak Fried(University of California, Los Angeles)Gary W. Mathern(University of California, Los Angeles)

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Abstract

The persistence of normal-appearing ripples in epileptic brain support the view that inhibitory processes are preserved. FRs appear to be field potentials reflecting hyper-synchronous bursting of excitatory neurons and provide an opportunity to study the role of this pathophysiologic phenomenon in epilepsy and seizure initiation. Furthermore, if FR activity is unique to brain areas capable of generating spontaneous seizures, its identification could be a powerful functional indicator of the epileptic region in patients evaluated for surgical treatment.

Neuroscience and Neuropharmacology Research Ion channel regulation and function Neuroscience and Neural EngineeringKainic acidHippocampal formationEntorhinal cortexNeuroscienceEpilepsyHippocampusPsychologyMedicineInternal medicineGlutamate receptor

MeSH terms

Action PotentialsAnimalsElectric StimulationElectrodes, ImplantedElectroencephalographyElectrophysiologyEpilepsy, Temporal LobeHippocampusHumansInterneuronsKainic AcidKindling, NeurologicFunctional LateralityMaleMicroelectrodes

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741

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High‐frequency oscillations: What is normal and what is not?