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CHRONIC TRAUMATIC ENCEPHALOPATHY IN A NATIONAL FOOTBALL LEAGUE PLAYER

Neurosurgery · 2006 · Vol. 59(5) · pp. 1086–1093

Bennet I. Omalu✉(Verizon (United States))Steven T. DeKosky(University of Pittsburgh)Ronald L. Hamilton(University of Pittsburgh)Ryan L. Minster(University of Pittsburgh)M. Ilyas Kamboh(University of Pittsburgh)Abdulrezak M. Shakir(University of Pittsburgh)Cyril H. Wecht(University of Pittsburgh)

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Abstract

Our first and second cases both had long careers without multiple recorded concussions. Both manifested Major Depressive Disorder after retirement. Amyloid plaques were present in the first case and completely absent in the second case. Both cases exhibited neurofibrillary tangles, neuropil threads, and coronary atherosclerotic disease. Apolipoprotein-E4 genotypes were different. Reasons for the contrasting features in these two cases are not clear. Further studies are needed to identify and define the neuropathological cascades of chronic traumatic encephalopathy in football players, which may form the basis for prophylaxis and therapeutics.

Genetic Neurodegenerative Diseases Takotsubo Cardiomyopathy and Associated Phenomena Glycogen Storage Diseases and MyoclonusChronic traumatic encephalopathyAutopsyMedicineAtrophyPathologyCerebral atrophyPsychiatryPoison controlConcussionInjury prevention