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Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain
The American Journal of Human Genetics · 2004 · Vol. 75(5) · pp. 807–821
Jingshan Chen✉(National Institutes of Health)Barbara K. Lipska(National Institutes of Health)Nader D. Halim(National Institutes of Health)Quang Trung(National Institutes of Health)Mitsuyuki Matsumoto(National Institutes of Health)Samer Melhem(National Institutes of Health)Bhaskar Kolachana(National Institutes of Health)Thomas M. Hyde(National Institutes of Health)Mary M. Herman(National Institutes of Health)José Apud(National Institutes of Health)Michael Egan(National Institutes of Health)Joel E. Kleinman(National Institutes of Health)Daniel R. Weinberger(National Institutes of Health)
Adipose Tissue and MetabolismMitochondrial Function and PathologyDiet and metabolism studiesCatechol-O-methyl transferaseMessenger RNAEnzymeMethyltransferaseEnzyme assayHuman brainGenetic variationBiologyMolecular biologyBiochemistry
MeSH terms
Analysis of VarianceAnimalsCatechol O-MethyltransferaseGenotypeHumansLymphocytesMethylationProteinsRNA, MessengerSex FactorsGenetic VariationBlotting, WesternGene Expression Regulation, EnzymologicMutagenesis, Site-DirectedPrefrontal Cortex
Funding
- National Institutes of Health
- National Institute of Mental Health
Citations
1,671
FWCI
24.67
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48
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100%
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References
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Psychopharmacology · 2004 · 547 citations
Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme
Biochemistry · 1995 · 1,166 citations
Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia
Molecular Psychiatry · 2002 · 810 citations
Psychopharmacology: The Fourth Generation of Progress
Psychiatric Services · 1996 · 1,150 citations
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Molecular Psychiatry · 2004 · 2,025 citations
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