review Open AccessTop 10% cited
Role of mitochondrial dysfunction in Alzheimer's disease
Journal of Neuroscience Research · 2002 · Vol. 70(3) · pp. 357–360
Rudy J. Castellani✉(Case Western Reserve University)Keisuke Hirai(Takeda (Japan))Gjumrakch Aliev(Case Western Reserve University)Kelly L. Drew(University of Alaska Fairbanks)Akihiko Nunomura(Asahikawa Medical College Hospital)Atsushi Takeda(Tohoku University)Ayla Cash(Case Western Reserve University)Mark E. Obrenovich(Case Western Reserve University)George Perry(Case Western Reserve University)Mark A. Smith✉(Case Western Reserve University)
Abstract
Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.
Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsBiochemical Acid Research StudiesDiseasePathologicalNeuroscienceAlzheimer's diseaseMitochondrionMedicineMitochondrial diseaseMitochondrial DNAPsychologyBiology
MeSH terms
Alzheimer DiseaseAnimalsBrainCytochromesDNA, MitochondrialEnergy MetabolismHumansMitochondriaMutationNeuronsOxidative StressMitochondrial Diseases
Citations
362
FWCI
5.36
field-weighted impact
References
30
Percentile
97%
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Citations per year
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References
Abnormalities of the electron transport chain in idiopathic parkinson's disease
Annals of Neurology · 1989 · 1,067 citations
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Annals of Neurology · 1997 · 1,785 citations
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
Trends in Genetics · 1990 · 1,396 citations
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