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Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections

AIDS · 2004 · Vol. 18(15) · pp. 2075–2079
Kate BuchaczPragna PatelMelanie TaylorPeter R. KerndtRobert H. ByersScott D. HolmbergJeffrey D. Klausner

Abstract

Syphilis infection was associated with significant increases in the HIV viral load and significant decreases in the CD4 cell count. The findings underscore the importance of preventing and promptly treating syphilis in HIV-infected individuals.

Syphilis Diagnosis and TreatmentReproductive tract infections researchHIV/AIDS Research and InterventionsSyphilisViral loadMedicineImmunologyLentivirusPrimary SyphilisSexually transmitted diseaseVirologyHuman immunodeficiency virus (HIV)Viral disease

MeSH terms

AdultHumansLymphopeniaMaleMiddle AgedRetrospective StudiesSyphilisHIV InfectionsCase-Control StudiesCD4 Lymphocyte CountViral LoadAntiretroviral Therapy, Highly Active

Funding

  • U.S. Department of Health and Human Services
  • AIDS Healthcare Foundation
  • Forskningsrådet om Hälsa, Arbetsliv och Välfärd
  • Centers for Disease Control and Prevention
Citations
449
FWCI
7.52
field-weighted impact
References
18
Percentile
98%
vs. same field & year
Citations per year
References
Cofactors in Male-Female Sexual Transmission of Human Immunodeficiency Virus Type 1
The Journal of Infectious Diseases · 1991 · 712 citations
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Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections · Scinovex